Patent · US Active

Methods of detecting amyotrophic lateral sclerosis (ALS)

US8753818B1 · kind B1 · utility

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14Claims
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Assignee

Inventors

Key dates

Filing dateMar 15, 2013
Grant dateJun 17, 2014
Priority date—
Expiry dateMar 15, 2033

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/156
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

In one aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising detecting one or more alterations in a profilin 1 (PFN1) sequence of an individual in need thereof compared to a wild type profilin sequence. In another aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising selectively sequencing a profilin 1 (PFN1) sequence of an individual in need thereof; and detecting one or more alterations in the PFN1 sequence of the individual. If the one or more alterations are detected then the individual has ALS.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.