8-fluorophthalazin-1(2H)-one compounds

US8754077B2 · kind B2 · utility

Assignee

• F. Hoffmann-La Roche AG · CH

Inventors

• James John Crawford · San Francisco, US
• Daniel Fred Ortwine · San Ramon, US
• BinQing Wei · Belmont, US
• Wendy B. Young · San Mateo, US

Key dates

• Filing date: Jan 13, 2014
• Grant date: Jun 17, 2014
• Expiry date: Jan 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

8-Fluorophthalazin-1(2h)-one compounds of Formula I where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.