Patent · US Active

Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof

US8754095B2 · kind B2 · utility

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12References
8Claims
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Assignee

Inventor

Key dates

Filing dateNov 6, 2012
Grant dateJun 17, 2014
Priority date—
Expiry dateNov 6, 2032

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D401/12
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure relates to a series of substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives of formula (I).wherein R, R1, R2, R3, R4, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure relates to methods of preparation of substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives of formula (I) and intermediates therefor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.