Modified food grade microorganism for treatment of inflammatory bowel disease

US8754198B2 · kind B2 · utility

Assignees

• University of Ljubljana · SI
• Institut Jozef Stefan · SI
• Labena d.o.o. · SI

Inventors

• Mojca Lunder · Ljubljana, SI
• Matjaz Ravnikar · Ljubljana, SI
• Borut Strukelj · Ljubljana, SI
• Ales Berlec · Žiri, SI
• Boris Ceh · Ljubljana, SI

Key dates

• Filing date: Jan 5, 2011
• Grant date: Jun 17, 2014
• Expiry date: Jan 5, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/035
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to microorganisms that express, or have attached to their surface, a TNFα binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNFα and therefore reducing the content of free TNFα and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.