Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin

US8758730B2 · kind B2 · utility

Assignee

• B.R.A.I.N. Biotechnology Research and Information Network AG · DE

Inventors

• Andreas Buthe · Steinfurt, DE
• Andreas Hafner · Gelterkinden, CH
• Franz Kaufmann · Glückstadt, DE
• Babette Fiedler · Darmstadt, DE
• Guido Meurer · Seeheim-Jugenheim, DE
• Gordon Bradley · Brampton, CA

Key dates

• Filing date: Feb 19, 2010
• Grant date: Jun 24, 2014
• Expiry date: Aug 14, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides the use of surface active proteins, especially class I and class II hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.