Aryl pyrimidine derivatives, preparation methods and pharmaceutical uses thereof

US8759355B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Yanbo Yang · Nanhu, CN
• Junhai Xiao · Beijing, CN
• Wu Zhong · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Xingzhou Li · Beijing, CN
• Yunde Xie · Beijing, CN
• Lili Wang · Beijing, CN
• Hongying Liu · Beijing, CN

Key dates

• Filing date: Jul 18, 2008
• Grant date: Jun 24, 2014
• Expiry date: May 22, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof. Various substituents in the formula (I) are as defined in the specification. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I), the preparation method of compound of formula (I), and the use of the compound for the preparation of a medicament for treating and/or preventing human peroxisome proliferators activated receptor δ (hPPARδ)-associated diseases and risk factors.