Amides as inhibitors of human secreted phospholipase A2

US8759392B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Edward A. Dennis · Village of La Jolla, US
• George Kokotos · Athens, GR
• Violetta Constantinou-Kokotou · Athens, GR
• Samuel David · Dorval, CA

Key dates

• Filing date: Jul 21, 2009
• Grant date: Jun 24, 2014
• Expiry date: Mar 31, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/51
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compounds useful for inhibiting a phoshpolipase A2 are provided, the methods comprising contacting the phoshpolipase A2 with a compound having the structure A, or pharmaceutically acceptable salts thereof: wherein R1 is H, F, NH2, or COOH; R2 is, H, linear saturated or unsaturated alkyl, alkenyl, or alkynyl; each of R3 and R4 is independently H, linear saturated or unsaturated alkyl, alkenyl, alkynyl, phenyl, or substituted phenyl; R5 is H, (C1-C6) alkyl such as methyl or ethyl; X is aryl or substituted aryl, such as phenyl or a substituted phenyl; and Y is O or S.