Chemokine binding activity of viral TNF receptors and related proteins
US8759485B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Sep 2, 2005 |
| Grant date | Jun 24, 2014 |
| Priority date | — |
| Expiry date | Feb 15, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70578
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumor necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in blocking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.