3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents

US8759537B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Henning Priepke · Warthausen, DE
• Henri Doods · Warthausen, DE
• Raimund Kuelzer · Mittelbiberach, DE
• Roland Pfau · Biberach, DE
• Dirk Stenkamp · Biberach, DE
• Benjamin Pelcman · Stockholm, SE
• Robert Roenn · Uppsala, SE

Key dates

• Filing date: Aug 17, 2011
• Grant date: Jun 24, 2014
• Expiry date: Aug 17, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula Itheir use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.