Methods for threshold determination in multiplexed assays
US8762068B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Oct 28, 2009 |
| Grant date | Jun 24, 2014 |
| Priority date | — |
| Expiry date | Jan 31, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06F18/24765
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for determination of threshold values of signatures comprised in an assay are described. Each signature enables detection of a target. The methods determine a probability density function of negative samples and a corresponding false positive rate curve. A false positive criterion is established and a threshold for that signature is determined as a point at which the false positive rate curve intersects the false positive criterion. A method for quantitative analysis and interpretation of assay results together with a method for determination of a desired limit of detection of a signature in an assay are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.