Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
US8763410B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 21, 2008 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | Jun 9, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/62
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.