System and method for forming bone, ligament, and bone-ligament constructs

US8764828B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Ellen M. Arruda · Ann Arbor, US
• Lisa M. Larkin · Ann Arbor, US
• Fatima N. Syed-Picard · Arlington, US
• Michael Smietana · Lake Orion, US
• Jinjin Ma · Ann Arbor, US

Key dates

• Filing date: Feb 4, 2008
• Grant date: Jul 1, 2014
• Expiry date: Jan 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.