Riluzole aqueous suspensions

US8765150B2 · kind B2 · utility

Assignee

• ITALFARMACO SPA · IT

Inventors

• Roberta Artico · Milano, IT
• Marco Adami · Milano, IT
• Daniele Barbareschi · Milano, IT
• Jaime G. Moscoso · Mount Prospect, US
• Tiziano Oldoni · Milano, IT
• Paolo Mascagni · Sesto San Giovanni, IT

Key dates

• Filing date: Mar 2, 2010
• Grant date: Jul 1, 2014
• Expiry date: Mar 2, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Physically and chemically stable aqueous oral suspensions of riluzole and manufacturing methods thereof. The suspensions contain riluzole in particle form and at least a wetting agent, preferably a surfactant. Riluzole is present in amounts from about 0.1% to about 20% w/v and has an average particle size lower than 200 μm. The suspensions are devoid of the known local (mouth) anaesthetic effects of riluzole.