Pharmaceutical or neutraceutical formulation

US8765152B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Rosario Lizio · Dieburg, DE
• Michael J. Gottschalk · Ober-Ramstadt, DE
• Michael Damm · Rödermark, DE
• Norbert Windhab · Hofheim, DE
• Melanie Liefke · Ober-Ramstadt, DE
• Guenter Schmitt · Darmstadt, DE
• Erna Roth · Darmstadt, DE
• Ruediger Alexowsky · Nauheim, DE

Key dates

• Filing date: Feb 25, 2010
• Grant date: Jul 1, 2014
• Expiry date: Feb 25, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/168
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a pharmaceutical or nutraceutical formulation comprising a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter and a bioavailability promoting agent, and a polymeric coating for the gastrointestinal targeted release of the active ingredient, characterized in that the bioavailability promoting agent is a pharmaceutically acceptable inhibitor of proteolytic enzymes, which increases the oral bioavailability of the active ingredient by a factor of at least five, compared to a corresponding formulation without the bioavailability promoting agent.