Patent · US Active

Cell cultivation process

US8765413B2 · kind B2 · utility

5Cited by

1References

18Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Christoph E. Joosten · Manlius, US
Christian Leist · Basel, CH
Jörg Schmidt · Schneeberg, DE

Key dates

Filing date	Apr 25, 2011
Grant date	Jul 1, 2014
Priority date	—
Expiry date	Apr 25, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2523/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product quality.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.