Manufacture of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase and uses thereof
US8765437B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jul 22, 2011 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | Jan 10, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/06004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compositions of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase (GALNS), and pharmaceutical compositions and formulations thereof, methods of producing and purifying GALNS, and its use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the GALNS enzyme, e.g., Mucopolysaccharidosis IVa (MPS IVa or Morquio A syndrome).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.