Cytotoxic benzodiazepine derivatives
US8765740B2 · kind B2 · utility
39Cited by
2References
56Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 15, 2012 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | Aug 30, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.