Heteroaryls and uses thereof

US8765746B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Brian Scott Freeze · Boston, US
• Masaaki Hirose · Yokohama, JP
• Hong Myung Lee · Cambridge, US
• Todd B. Sells · Bellingham, US
• Zhan Shi · Concord, US
• Leo R. Takaoka · Newton, US
• Stepan Vyskocil · Arlington, US
• Tianlin Xu · Shrewsbury, US

Key dates

• Filing date: Oct 13, 2011
• Grant date: Jul 1, 2014
• Expiry date: Oct 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides compounds of formula I-A or I-B:wherein HY, G1, G2, R2, R12, W1, W2, n, and Ring A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.