Substituted piperazines as CGRP antagonists

US8765763B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Alexander Dreyer · Ochsenhausen, DE
• Henri Doods · Warthausen, DE
• Kai Gerlach · Biberach, DE
• Dirk Gottschling · Mittelbiberach, DE
• Annekatrin Heimann · Biberach, DE
• Stephan Georg Mueller · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Gerhard Schaenzle · Biberach, DE

Key dates

• Filing date: Jun 2, 2010
• Grant date: Jul 1, 2014
• Expiry date: Oct 2, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new CGRP-antagonists of general formula Iwherein R1, R2, R3, Ra, Rb, Rc, X, Y and Z are defined as mentioned hereinafter, the individual diastereomers, the individual enantiomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, the use thereof and processes for the preparation thereof.