TOX3 as a biomarker for breast cancer
US8765919B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 4, 2012 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | Jun 4, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides compositions and methods for detecting and/or modulating TOX3 gene expression and/or biological activity. Such compositions and methods find utility in the detection and/or treatment of certain subsets of cancers, e.g. breast cancer. In particular, the inventive compositions and methods are drawn to production and use of anti-TOX3 antibodies and TOX3 nucleic acids for both detection and modulation of TOX3. The invention also provides for pharmaceutical compositions and methods for the modulation of TOX3 in a subject in need thereof. Further aspects of the invention relate to transgenic mice that either over-express or inducibly express TOX3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.