Asymmetric aldol additions using bifunctional cinchona-alkaloid-based catalysts
US8765955B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | May 26, 2006 |
| Grant date | Jul 1, 2014 |
| Priority date | — |
| Expiry date | May 26, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
One aspect of the present invention relates to asymmetric catalytic nitroaldol (Henry) reactions with ketones as the electrophilic component. In one embodiment, the present invention relates to asymmetric nitroaldol reactions with α-keto esters catalyzed by a new C6′-OH cinchona alkaloid catalyst. In certain embodiments, this reaction is operationally simple and affords high enantioselectivity as well as good to excellent yield for an exceptionally broad range of α-keto esters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.