Patent · US Active

Process for the preparation of 2,2-difluoroethylamine starting from prop-2-en-1-amine

US8766012B2 · kind B2 · utility

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2References

20Claims

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Assignee

BAYER CROPSCIENCE AKTIENGESELLSCHAFT · DE

Inventors

Norbert Lui · Odenthal, DE
Christian Funke · Leichlingen, DE
Jens-Dietmar Heinrich · Burscheid, DE
Thomas Muller · Bad Homburg vor der Höhe, DE

Key dates

Filing date	Nov 9, 2011
Grant date	Jul 1, 2014
Priority date	—
Expiry date	Jan 29, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C211/15
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the preparation of 2,2-difluoroethylamine of the formula (I)CHF2CH2NH2 (I)comprising the stages (i) and (ii):stage (i): reaction of 2,2-difluoro-1-haloethane of the formula (II)CHF2—CH2Hal (II)in which Hal is chlorine, bromine or iodine,with prop-2-en-1-amine of the formula (III)to give N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV)preferably in the presence of an acid scavenger,andstage (ii): removal of the allyl group from the N-(2,2-difluoroethyl)prop-2-en-1-amine of the formula (IV) obtained in stage (i) to give 2,2-difluoroethylamine of the formula (I) or a salt thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.