Soluble recombinant influenza antigens
US8771703B2 · kind B2 · utility
14Cited by
8References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2009 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Jan 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a recombinant soluble trimeric hemagglutinin (rHA) protein comprising a hemagglutinin ectodomain and an oligomerization domain. The rHA is produced as a soluble homotrimer, and may further comprises a signal peptide and/or an endoplasmic reticulum (ER) retention signal. The invention is also directed to nucleic acids encoding the rHA of the invention, as well as vectors and chimeric constructs comprising the nucleic acid. Methods of producing the rHA are also provided. The rHA described herein may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.