In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles
US8771741B2 · kind B2 · utility
14Cited by
1References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 2010 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Oct 12, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.