Peptide antibody depletion and its application to mass spectrometry sample preparation
US8771969B2 · kind B2 · utility
2Cited by
1References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2012 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Jun 28, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25125
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other methods; analytic (diagnostic) methods using antibodies against highly ionizable peptides from a protein target of interest; and compositions, kits and devices comprising antibodies of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.