Engineered cleavage half-domains
US8771986B2 · kind B2 · utility
35Cited by
36References
18Claims
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Key dates
| Filing date | Sep 21, 2011 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Mar 6, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.