Mediators of hedgehog signaling pathways, compositions and uses related thereto

US8772275B2 · kind B2 · utility

Assignee

• Curis, Inc. · US

Inventors

• Lee L. Rubin · Wellesley, US
• Oivin Guicherit · San Diego, US
• Stephen Price · Hertford, GB
• Edward Andrew Boyd · Biggenden, AU

Key dates

• Filing date: Dec 12, 2012
• Grant date: Jul 8, 2014
• Expiry date: Dec 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.