Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same
US8772290B2 · kind B2 · utility
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4References
8Claims
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Key dates
| Filing date | Apr 21, 2011 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Apr 21, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.