Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists

US8772323B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Grauert · Ingelheim am Rhein, DE
• Remko Alexander BAKKER · Biberach an der Riß, DE
• Steffen Breitfelder · Aßmannshardt, DE
• Frank Buettner · Biberach an der Riß, DE
• Peter Eickelmann · Mittelbiberach, DE
• Thomas Fox · Biberach, DE
• Marc Grundl · Biberach an der Riß, DE
• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Wolfgang Rist · Ingelheim am Rhein, DE

Key dates

• Filing date: May 6, 2011
• Grant date: Jul 8, 2014
• Expiry date: May 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.