Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity

US8772326B2 · kind B2 · utility

Assignee

• Anigion Biomedica Corp. · US

Inventors

• Weizhong Cai · Dix Hills, US
• Prakash Narayan · East Northport, US
• Bijoy Panicker · Holbrook, US
• David E. Smith · Vancouver, US

Key dates

• Filing date: Jul 9, 2009
• Grant date: Jul 8, 2014
• Expiry date: Nov 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.