Substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators

US8772504B2 · kind B2 · utility

Assignees

• Janssen Pharmaceuticals, Inc. · BE
• Cellzome Limited · GB

Inventors

• Henricus Jacobus Maria Gijsen · Breda, NL
• François Paul Bischoff · Vosselaar, BE
• Wei Zhuang · Monheim, DE
• Sven Franciscus Anna Van Brandt · Nijlen, BE
• Michel Surkyn · Kessel-Lo, BE
• Mirko Zaja · Birkenfeld, DE
• Didier Jean-Claude Berthelot · Edegem, BE
• Michel Anna Jozef De Cleyn · Merksplas, BE
• Gregor James MacDonald · Zoersel, BE
• Daniel Oehlrich · Brecht, BE

Key dates

• Filing date: Feb 15, 2010
• Grant date: Jul 8, 2014
• Expiry date: Jun 25, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I)wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.