Crystals and structure of a human IgG Fc variant with enhanced FcRn binding
US8775090B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Dec 10, 2009 |
| Grant date | Jul 8, 2014 |
| Priority date | — |
| Expiry date | Jun 8, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.