Angiogensis models using nestin-expressing stem cells to image nascent blood vessels
US8778308B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 28, 2004 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Oct 28, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5073
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.