Fluorescent pyrazine derivatives and methods of using the same in assessing renal function
US8778309B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 2005 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Mar 14, 2029 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/1206
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pyrazine derivatives represented by Formula I. X1 and X2 of Formula I may be characterized as electron withdrawing groups, while Y1 and Y2 of Formula I may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing organ (e.g., kidney) function. In a particular example, an effective amount of a pyrazine derivative that is capable of being renally cleared may be administered into a patient's body. The pyrazine derivative may be capable of one or both absorbing and emanating spectral energy of at least about 400 nm (e.g., visible and/or infrared light). At least some of the derivative that is in the body may be exposed to spectral energy and, in turn, spectral energy may emanate from the derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.