Bone formation agent and method of production

US8778374B2 · kind B2 · utility

Assignee

• CURASAN AG · DE

Inventors

• Dieter Reif · Altendambach, DE
• Fabian Peters · Frankfurt am Main, DE
• Frank Palm · Munich, DE
• Joachim Wittner · Frankfurt am Main, DE

Key dates

• Filing date: Jun 25, 2004
• Grant date: Jul 15, 2014
• Expiry date: May 12, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C04B2235/94
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention relates to a bone formation agent of porous calcium phosphate having an isotropic sintered structure and, between the particles of the calcium phosphate, statistically distributed pores in a plurality of discrete size ranges. The bone formation agent has at least two, preferably three, discrete pore size distributions. Its porosity has an irregular geometric shape. The sintered particles of the calcium phosphate have a particle size smaller than 63 μm with a d50 value in the range from 5 to 20 μm. The interconnecting pore share in the overall porosity is limited to pore sizes less than 10 μm. The bone formation agent can be used in the form of a granulate or shaped body for bone regeneration. In the case of granulates, the maximum pore diameters are matched to the granulate diameter. The invention relates also to a method of producing the bone formation agent.