Multi-unit gastroretentive pharmaceutical dosage form comprising microparticles

US8778396B2 · kind B2 · utility

Assignee

• UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG · ZA

Inventors

• Viness Pillay · Sandton, ZA
• Yahya Essop Choonara · Lenasia, ZA
• Caragh Murphy · Milnerton, ZA
• Sarashnee Moonisami · Midrand, ZA

Key dates

• Filing date: Jun 3, 2009
• Grant date: Jul 15, 2014
• Expiry date: Jan 24, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/209
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to an orally administrable, gastroretentive pharmaceutical dosage form which contains at least one pharmaceutically active ingredient and at least one polymeric adjuvant. The adjuvant serves to retain the dosage form in a selected region of the gastrointestinal tract for sufficient time for the pharmaceutically active ingredient to be released and absorbed. Ideally the dosage form will contain two or more pharmaceutically active ingredients which are delivered to different regions of the gastrointestinal tract.