Patent · US Active

Chemo-enzymatic approach to the synthesis of pimecrolimus

US8778636B2 · kind B2 · utility

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35Claims

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Assignee

EUTICALS SPA · IT

Inventors

Paride Grisenti · Milano, IT
Shahrzad Reza Elahi · Milano, IT
Elisa Verza · Magenta, IT

Key dates

Filing date	May 19, 2010
Grant date	Jul 15, 2014
Priority date	—
Expiry date	May 11, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/18
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.