Modified gram-negative bacteria for use as vaccines
US8778655B2 · kind B2 · utility
4Cited by
1References
4Claims
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Key dates
| Filing date | Sep 21, 2010 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Sep 21, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/552
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.