Structured peptide processing
US8778844B2 · kind B2 · utility
18Cited by
0References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2010 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Aug 30, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more reactive groups which form a covalent linkage to the molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; exposing the peptide ligands to one or more proteases; and sorting the ligands according to the extent of proteolytic cleavage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.