Patent · US Active

Amide based glucagon superfamily peptide prodrugs

US8778872B2 · kind B2 · utility

34Cited by

19References

25Claims

0Family size

Assignee

INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION · US

Inventors

Richard D. DiMarchi · Carmel, US
Binbin Kou · Bloomington, US

Key dates

Filing date	Jun 14, 2011
Grant date	Jul 15, 2014
Priority date	—
Expiry date	Jun 14, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.