Substituted phenylpiperazinyl aralkylalcohol derivatives, pharmaceutical compositions containing such derivatives and uses thereof

US8778948B2 · kind B2 · utility

Assignee

• NHWA PHARMA. CORPORATION · CN

Inventors

• Jianqi Li · Shanghai, CN
• Guan Wang · Shanghai, CN
• Guisen Zhang · 安丰镇, CN
• Xiangping Yang · Xuzhou, CN
• Peng Xie · Xiamen, CN
• Linjie Zhang · Taiyuan, CN
• Xiangqing Xu · Xuzhou, CN
• Yumei WANG · Beijing, CN

Key dates

• Filing date: Dec 22, 2009
• Grant date: Jul 15, 2014
• Expiry date: Aug 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/096
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a substituted phenylpiperazine aryl alkanol derivative represented by the following general formula and its salt and hydrate,wherein C1 and C2 represent chiral carbon atoms, and the compound is one of the six isomers: (1RS, 2SR), (1RS, 2RS), (1R, 2S), (1S, 2S), (1R, 2R) or (1S, 2R); and R, R1, R2, R3 and Ar are as defined in the specification. The derivative is non-opioid analgesic, has good analgesic effect and relatively small side effects. The invention also relates to a composition comprising the derivative and its use.