Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US8778967B2 · kind B2 · utility
17Cited by
23References
20Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 25, 2012 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Jan 25, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.