Male contraceptive

US8778968B2 · kind B2 · utility

Assignees

• Nnaemkea Ikechukwu Amobi · GB
• Ian Christopher Smith · GB

Inventors

• Nnaemeka Ikechukwu Amobi · London, GB
• Ian Smith · Dunleer, IE

Key dates

• Filing date: Jul 16, 2009
• Grant date: Jul 15, 2014
• Expiry date: Oct 28, 2031

Classification

• Technology area (CPC —): General

Abstract

A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.