Patent · US Active

Trisubstituted 1,2,4 triazoles

US8778974B2 · kind B2 · utility

2Cited by

5References

4Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Gregor James MacDonald · Zoersel, BE
Johannes Wilhelmus John F. Thuring · Ekeren, BE
Pauline Stanislawski · Whittlesea, AU
Wei Zhuang · Monheim, DE
Yves Emiel Maria Van Roosbroeck · Heist-op-den-Berg, BE
Frans Alfons Maria Van den Keybus · Beerse, BE

Key dates

Filing date	Mar 18, 2009
Grant date	Jul 15, 2014
Priority date	—
Expiry date	Mar 3, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to 1-aryl-3-aniline-5-alkyl-1,2,4-triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).The invention particularly relates to potent positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.