Hydroxybenzoate salts of metanicotine compounds
US8778978B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 2013 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Oct 3, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/75
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.