Saccharide free, storage stable thyroid hormone active drug formulations and methods for their production
US8779000B1 · kind B1 · utility
10Cited by
5References
23Claims
0Family size
Inventors
Key dates
| Filing date | Jul 20, 2013 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Jul 20, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2013
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the present invention provide pharmaceutical compositions in unit dosage form that comprise a therapeutically effective amount of levothyroxine sodium; an antioxidant in an amount sufficient to stabilize the levothyroxine sodium against oxidation; an amount of an alditol sufficient to stabilize the levothyroxine sodium; and at least two excipients selected from a filler, a binder, and a lubricant. Such compositions are free of added monosaccharide, disaccharide, and an oligosaccharide and are storage stable.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.