Low viscosity highly concentrated suspensions
US8779094B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 2009 |
| Grant date | Jul 15, 2014 |
| Priority date | — |
| Expiry date | Feb 2, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/113
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention also provides a high concentration low viscosity suspension of an pharmaceutically acceptable solvent with one or more sub-micron or micron-sized non-crystalline particles comprising one or more proteins or peptides. Optionally one or more additives in the pharmaceutically acceptable solvent to form a high concentration low viscosity suspension with a concentration of at least 20 mg/ml and a solution viscosity of between 2 and 100 centipoise that is suspendable upon shaking or agitation, wherein upon delivery the one or more sub-micron or micron-sized peptides dissolves and do not form peptide aggregates syringeable through a 21 to 27-gauge needle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.