EMP2 antibodies and methods of use thereof causing regression of a solid tumor or symptoms thereof

US8779104B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Jonathan Braun · Calabasas, US
• Lynn K. Gordon · Calabasas, US
• Kaori Shimazaki Dadgostar · Los Angeles, US
• Madhuri Wadehra · Manhattan Beach, US
• Kathleen A. Kelly · Santa Monica, US
• Anna M. Wu · West Hollywood, US

Key dates

• Filing date: Aug 21, 2013
• Grant date: Jul 15, 2014
• Expiry date: Aug 21, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interaction between the Chlamydia and EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.