Patent · US Active

Trisubstituted pyrazoles as acetylcholine receptor modulators

US8779158B2 · kind B2 · utility

0Cited by

5References

7Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Johannes Wilhelmus John F. Thuring · Ekeren, BE
Gregor James MacDonald · Zoersel, BE
Wei Zhuang · Monheim, DE

Key dates

Filing date	May 8, 2009
Grant date	Jul 15, 2014
Priority date	—
Expiry date	Mar 22, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.