Patent · US Active

Compositions and methods for treatment of angiogenesis in pathological lesions

US8784824B2 · kind B2 · utility

2Cited by

9References

24Claims

0Family size

Assignee

PHILOGEN S.P.A. · IT

Inventors

Luciano Zardi · Genova, IT
Dario Neri · Zürich, CH
Barbara Carnemolla · Genova, IT
Fredrik Nilsson · Stockholm, SE
Lorenzo Tarli · Siena, IT
Laura Borsi · Genova, IT
Cornelia Halin · Zürich, CH

Key dates

Filing date	Jul 14, 2010
Grant date	Jul 22, 2014
Priority date	—
Expiry date	Jul 14, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration, and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12 (IL-12), Interferon-γ (IFN-γ), Tumor Necrosis Factor α (TNFα) or Tissue Factor protein (which may be truncated).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.